Session WOE. There are 2 abstracts in this session.



Session: Tutorial, time: 4:00-4:40

In Vivo MR - Spectroscopic Content:  How to Validate and Test Repeatability of Short TE Proton MR Spectroscopy.


Ralph Hurd1; Meng Gu1; Laima Baltusis2; Daniel Spielman1
1Radiology, Stanford University, Stanford, CA; 2CNI Stanford University, Stanford, CA
A recent surge of interest in MR spectroscopy and standardization is documented in a recent consensus paper, and is further evidenced by a dramatic growth of the MR spectroscopy workgroup at the ISMRM. In addition to a developing Clinical focus based on fully automated 2-3 minute spectroscopic exams, academic support centers that cater to the application-driven synergy between functional and metabolic MR have also become popular. In these environments, spectral editing and single voxel spectroscopy have both seen success.  Validations of the more buried metabolites are important for these applications.  This tutorial will review the metabolic content of short-TE spectra collected at 3T, along with methods for validation using phantoms and repeatability data.

Session: Tutorial, time: 4:40-5:20

Biomolecular Solid-State NMR


Tatyana Polenova
University of Delaware, Newark, DE
In this tutorial, a practical introduction to modern biological solid-state NMR spectroscopy will be presented, aimed at students and the general audience of scientists interested in entering the field. General protocols for protein structure determination and dynamics studies by magic angle spinning NMR will be outlined. The basic building blocks of solid-state MAS NMR experiments will be discussed, including polarization transfer, dipolar and scalar recoupling. An overview of 2D and 3D MAS NMR experiments for protein structural biology will be given. Emerging experiments for fast and ultrafast MAS conditions will be described.