Session TOE. There are 3 abstracts in this session.



Session: Instrumentation 2, time: 4:00-4:40

Optimization of multi-channel MAS probes for solid-state NMR of deuterated biomolecules


Jessica Kelz; John Kelly; Rachel W. Martin
UC Irvine, Irvine, CA
Extensive deuteration is often used in protein solid-state NMR to simplify the 1H spectra. However, this usually comes at the expense of losing those protonated sites as NMR-active nuclei. Using 2H in multidimensional correlation experiments will enable more efficient C-N magnetization transfer, made possible by the fast repetition times due to rapid 2H relaxation. My group has designed and built a 1H/13C/2H/15N MAS NMR probe for investigation of deuterated biomolecules at 18.8 T. This presentation will focus on strategies for optimizing the performance of this crossed-coil probe, in particular enhancing the reproducibility of coil fabrication and ensuring alignment of the two coils. In particular, 3D printing enables coil forms and inserts to be produced easily and inexpensively.

Session: Instrumentation 2, time: 4:40-5:20

NMR spectroscopy with femtomole sensitivity using quantum defects in diamond


Ronald Walsworth
Harvard University, Cambridge, MA
Recently, a new class of NMR sensors based on optically-probed nitrogen-vacancy (NV) quantum defects in diamond has allowed molecular spectroscopy from picoliter sample volumes, several orders of magnitude smaller than the most sensitive inductive detectors. In addition, hyperpolarization techniques have been integrated with NV-NMR, enabling high-resolution spectroscopy on small molecules in dilute solution with femtomole sensitivity.  I will provide an overview of this rapidly advancing technology, including its challenges and potential applications.

Session: Instrumentation 2, time: 5:20-6:00

MR-to-go: Making magnetic resonance mobile using integrated circuit technology


Jens Anders1; Jan Korvink2; Bernhard Bluemich3; Klaus Lips4
1University of Stuttgart, Stuttgart, Germany; 2Karlsruhe Institute of Technology, Freiburg, N/A; 3RWTH Aachen University, Aachen, Germany; 4Helmholtz Zemtrum Berlin, Berlin, N/A
The recent availability of the NMR- and EPR-on-a-chip technology, which allows to integrate the entire MR spectrometer electronics and even the detection coil into a single CMOS ASIC (application specific integrated circuit), allows for drastic reductions in the size, complexity and cost of MR spectrometers. Moreover, new detection techniques enabled by the recently proposed voltage controlled oscillator (VCO) based MR detection approach, enable significant performance boosts in spin sensitivity. In this invited talk, the new possibilities of the MR-on-a-chip technology both for the realization of new mobile in-field and in-situ applications as well high performance MR sensing will be discussed.