Session FOC. There are 3 abstracts in this session.



Session: Hyperpolarization 2, time: 11:00am-11:40am

Design of Solid Polarization Matrixes for Efficient Dynamic Nuclear Polarization
 


Christophe Copéret
ETH Zurich, Zurich, Switzerland
Dynamic Nuclear Polarization (DNP) can efficiently enhance NMR signals by several order of magnitudes, both in solution (dissolution DNP – several 10’000) and in the solid state (solid-state DNP at 100 K – several 100). DNP relies on the efficient transfer of polarization from polarized electrons to NMR active nuclei, and it can be carried out using homogeneous distribution of organic radicals within a glassy matrix under microwave irradiation at low temperatures. However, one of the great challenges often remains to obtain adequate formulation and to generate reproducible glassy matrixes. This presentation will thus focus on the development of efficient hydrid organo-silica materials towards efficient DNP at low temperatures.
 

Session: Hyperpolarization 2, time: 11:40am-12:20pm

Making Triplet Dynamic Nuclear Polarization More Accessible and Feasible


Nobuhiro Yanai1, 2
1Kyushu University, Fukuoka, Japan; 2JST-PRESTO, Kawaguchi, Japan
While dynamic nuclear polarization based on photo-excited triplet electrons (triplet-DNP) has the potential to hyperpolarize nuclear spins of target substrates in the low magnetic field at room temperature, there has been no triplet-DNP system offering structural rigidity and substrate accessibility. Here, we report the first example of triplet-DNP of nanoporous metal-organic frameworks (MOFs). Another challenge of triplet-DNP is the poor air-stability of the typical polarizing agent, pentacene. We demonstrate new polarizing agents with significant air-stability as well as high polarizing ability comparable to pentacene.
 

Session: Hyperpolarization 2, time: 12:20pm-1:00pm

Achieving the Hyperpolarisation of Pyruvate, Glucose and Urea via SABRE


Simon Duckett; Wissam Iali; Soumya Roy; Fadi Ahwal; Ben Tickner; Peter Rayner; Peter Richardson; Aneurin Kennerley
University of York, York, United Kingdom
The Signal Amplification by Reversible Exchange (SABRE) process harnesses parahydrogen to sensitise the MR detection of agents through the catalytic transfer of nuclear spin order. While SABRE has been reported to hyperpolarise a growing range of materials that contain nitrogen centres, there is a need to improve its chemical diversity. Results are described that demonstrate it is now possible to target a much larger array of substrates with this simple hyperpolarisation technique, including the important molecules pyruvate, urea and glucose.